Essential details
Shipping:Express Delivery
Product Introduction
The Next-Generation Probiotic for Mucosal Integrity
Akkermansia muciniphilais a strictly anaerobic, mucin-degrading Gram-negative bacterium naturally colonizing the intestinal mucus layer. AKK PROBIO is a scientifically validated strain with dual-form availability (Live & Pasteurized), recognized for restoring gut barrier function and modulating the microbiota-metabolite axis. Unlike conventional lactic acid bacteria, AKK directly interacts with the mucus layer, enhancing tight junction protein expression (ZO-1, Occludin) and reducing metabolic endotoxemia.
Core Mechanism: Mucin Degradation → Mucus Layer Thickening → Tight Junction Reinforcement → Reduced Leaky Gut → Systemic Inflammatory Control.
Core Advantages
1. Mucus Layer Colonizer
Naturally inhabits the gut mucosa; stimulates host mucin (MUC2) secretion to reinforce the physical gut barrier.
2. Dual-Form Efficacy
Available as Live Probiotic (>10¹² AFU/g) and Pasteurized Postbiotic (retaining Amuc_1100/P9 bioactive proteins).
3. Global IP & Compliance
8~9 Authorized Chinese Invention Patents + 6 HK Patents; US FDA GRAS (Live & Inactivated); Non-GMO.
4. Safety Validated
Acute/Sub-chronic toxicity tests passed; Micronucleus test negative; Antibiotic resistance gene (e.g., moxifloxacin) non-transferable.
5. High Potency & Scale
Fermentation >10¹⁰ CFU/mL; Lyophilized powder ≥10¹² AFU/g; Annual capacity 30 tons.
6. Sci-Backed
3 SCI papers (Foods, JFF, Food Sci Nutr); Safety & colorectal cancer/gout arthritis models published.
Gut Health Benefits
①Gut Barrier Restoration: Upregulates ZO-1and Occludin, reverses increased intestinal permeability induced by Western diets.②Microbiota Rebalancing: Increases Verrucomicrobiaabundance; suppresses pathogenic overgrowth (e.g., Clostridium).
③IBD & Colorectal Support: Alleviates DSS-induced colorectal tumors in mice; modulates inflammatory cytokines (IL-6↓, IL-10↑).
④Systemic Immunity: Enhances SCFA (acetate/propionate) production; linked to improved PD-1/PD-L1 checkpoint inhibitor response in NSCLC (Nature Medicine).
⑤Brain-Gut Axis: Improves cognitive dysfunction via BDNF/5-HT upregulation; linked to ASD gut permeability improvement.
Recommended Applications
Dietary Supplements: Synbiotic capsules, gut health powders, postbiotic tablets.
Medical Nutrition: Formulas for leaky gut, IBD support, antibiotic recovery.
Functional Foods: Gut-health beverages, fermented dairy alternatives.
Medical Nutrition: Formulas for leaky gut, IBD support, antibiotic recovery.
Functional Foods: Gut-health beverages, fermented dairy alternatives.
Clinical Research: Immuno-oncology adjuvants (PD-1 response biomarker).
Animal Gut Health: Livestock mucosal health, antibiotic alternative.
Typical Specifications
| Product Name | Akkermansia muciniphila AKK PROBIO |
| Strain ID | CGMCC No.20955 |
| Form | Freeze-dried Powder (Live / Pasteurized) |
| Appearance | Off-white to Beige Fine Powder |
| Biomass | ≥ 2.0×10¹¹ ~ 3.0×10¹¹ AFU/g (n-AFU/g) |
| Live Count | <10 CFU/g (Pasteurized) / ≥10¹² AFU/g (Live) |
| Moisture | ≤ 5.0% |
| Total Plate Count | ≤ 1,000 CFU/g |
| Pathogens | E. coliNeg; SalmonellaNeg; S. aureusNeg |
| Shelf Life | 24 Months (Sealed, Cool Dry Place) |
| Packaging | 5kg/bag (PE + Al-foil); 25kg/drum |