Essential details
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Product Introduction
Chemical Property:
| Name | 2,4-Difluorobenzylamine |
| Synonyms | RARECHEM AL BW 0282 2,4-Fluorobenzylamine 2,4-DIFLUOROBENZYLAMINE 2,4-Difluorobenzylamine 2,4-Difluorobenzyl Amine 2,4-Difluorobenzenemethanamine (2,4-Difluorophenyl)methanamine Benzenemethanamine, 2,4-difluoro- 1-(2,4-difluorophenyl)methanamine (2,4-difluorophenyl)methanaminium 2,4-DIFLUOROBENZYLAMINE HYDROCHLORIDE |
| CAS | 72235-52-0 |
| EINECS | 276-502-0 |
| InChI | InChI=1/C7H7F2N/c8-6-2-1-5(4-10)7(9)3-6/h1-3H,4,10H2/p+1 |
| InChIKey | QDZZDVQGBKTLHV-UHFFFAOYSA-N |
72235-52-0 - Physico-chemical Properties
| Molecular Formula | C7H7F2N |
| Molar Mass | 143.13 |
| Density | 1.204 g/mL at 25 °C (lit.) |
| Melting Point | 255-256 °C(Solv: N,N-dimethylformamide (68-12-2)) |
| Boling Point | 82-84 °C (15 mmHg) |
| Flash Point | 155°F |
| Vapor Presure | 1.02mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.204 |
| Color | Clear colorless to light yellow |
| BRN | 3539259 |
| pKa | 8.58±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.49(lit.) |
72235-52-0 - Risk and Safety
| Hazard Symbols | C – Corrosive Failed to download the external image. To let the recipient see this image, please delete the image, then download it locally and paste it into the email. https://res.chembk.com/assets/images/hs/C.gif Delete |
| Risk Codes | 34 – Causes burns |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 – Take off immediately all contaminated clothing. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 – Avoid contact with eyes. |
| UN IDs | UN 2735 8/PG 3 |
| WGK Germany | 3 |
| HS Code | 29214990 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | III |
| Application Sector | Key Uses |
|---|---|
| Pharmaceuticals (API Synthesis) | Key building block for antiviral drugs (e.g., HIV protease inhibitors, HCV NS3/4A inhibitors), anticancer agents (kinase inhibitors, PARP inhibitors), and CNS drugs. The difluorobenzylamine moiety is found in molecules such as fluvoxamine (SSRI antidepressant), voriconazole (antifungal), and various investigational compounds. |
| Agrochemicals | Used in the synthesis of modern fluorinated pesticides, including fungicides (e.g., fluopyram analogs), herbicides, and insecticides. Fluorine substitution improves environmental stability and target selectivity. |
| Peptide/Peptidomimetic Chemistry | Serves as a precursor for fluorinated benzylamine derivatives used in peptide modification and PROTAC (proteolysis-targeting chimera) linkers. |
| Fine Chemical Synthesis | Intermediate for manufacturing specialty amines, amides, Schiff bases, and heterocyclic compounds (e.g., benzimidazoles, quinazolines) with enhanced bioactivity. |
| Material Science | Used in the production of fluorinated polymers, liquid crystal displays (LCDs), and functional coatings requiring unique electronic properties. |
Xinchem is a premier 2,4-difluorobenzylamine manufacturer with deep fluorination chemistry expertise and robust CDMO capabilities:
| Parameter | Capability |
|---|---|
| Annual Production Capacity | 200+ metric tons (expandable) |
| Purity Grade | Pharmaceutical grade (≥99.0% GC), Research grade (≥98.0%), Custom purity (up to 99.9%) |
| Custom Synthesis | Tailored substitution patterns (mono-, di-, trifluorinated benzylamines), isotopically labeled analogs (²H, ¹³C, ¹⁵N), derivative synthesis (amides, carbamates, sulfonamides, ureas, Schiff bases) |
| Process Development | Route optimization for cost-effective scale-up; continuous flow fluorination available |
| Packaging Options | 1 kg, 5 kg, 25 kg drum, 50 kg HDPE drum, 200 kg steel drum, custom packaging |
| MOQ (Bulk/Wholesale) | 100 g (R&D samples); 100 kg (bulk orders) |
| Lead Time | 3–5 days for in-stock; 14–21 days for custom synthesis |
| Export Markets | USA, EU (Germany, Switzerland, UK, France), Japan, South Korea, Russia, India |
| Logistics | Ambient or refrigerated shipping; professional handling of corrosive (Class 8) materials |
