Introduction Carbamic acid, [(1S)-2-oxo-1-(phenylmethyl)-3-butenyl]-, 1,1-dimethylethyl ester (9CI)(CAS#137278-22-9)

Physical properties and appearance
Status: Colorless to pale yellow liquid
Solubility: soluble in common organic solvents such as dichloromethane, ethyl acetate, and ether, slightly soluble in water
Stability: Sensitive to moisture and strong alkali, Boc groups can be deprotected under acidic conditions, and need to be stored in a dry, inert atmosphere
Boiling point/melting point: Boiling point>200 ° C
Note: As this compound is a highly active intermediate, commercial suppliers usually provide it in solution form to avoid long-term storage of pure products.
Main uses and application areas
Core application: Chiral building unit in drug synthesis
Typical application scenarios:
As a Boc protected allyl carbamate, it is used to construct peptide or non peptide drug scaffolds containing phenylalanine derivatives
Participate in nucleophilic addition and cyclization reactions to synthesize nitrogen-containing heterocyclic compounds (such as pyrrolidine and pyridine derivatives)
As a key intermediate in the synthesis pathway of antiviral and anti-tumor drugs