I-Chemoselective Bifunctional Alkylating Agent Yokwenziwa kwe-Pentoxifylline, Ama-Pharmaceutical Intermediates, kanye Nama-Specialty Agrochemicals (CAS# 10226-29-6)

I-6-Bromohexan-2-one (CAS# 10226-29-6), eyaziwa nangokuthi i-6-bromo-2-hexanone, i-5-oxohexyl bromide, i-1-bromo-5-hexanone, noma i-4-bromobutyl methyl ketone, iyi-C6 aliphatic bromoketone enefomula yamangqamuzana i-C₆H₁₁BrO kanye nesisindo samangqamuzana esingu-179.05 g/mol. Isakhiwo sayo sihlanganisa i-terminal primary alkyl bromide kwelinye icala kanye ne-methyl ketone kwelinye icala le-flexible four-carbon methylene chain. Lokhu kuyenza ibe yisakhi esisetshenziswayo se-bifunctional building block ekuguquleni okulandelanayo kwe-chemoselective.

Le nhlanganisela iwuketshezi emazingeni okushisa asendaweni enokuminyana okungu-1.3496 g/cm³ ku-0°C, izinga lokubila elingu-214–215°C ku-95.76 kPa ngokubola, inkomba yokukhanya engu-1.4890, kanye ne-LogP engu-2.14. Iyancibilika ku-chloroform, kuma-alcohol, kanye nama-ether, kodwa ayincibiliki emanzini.

Ngokungafani nama-alkyl halides anomsebenzi owodwa, i-6-bromohexan-2-one inezindawo ezimbili ezisebenzayo ezihlukene: i-bromide eyinhloko iba ne-nucleophilic substitution (SN2) nama-amines, ama-alkoxides, nama-thiols, kuyilapho i-ketone ingaba neqhaza ku-condensation, ukunciphisa, i-reductive amination, kanye nokuguqulwa okuhlobene. Lokhu kusebenza kabili kuyenza ibe yisikhungo esibalulekile ngokwesu ekukhiqizeni imithi, ukuhlanganiswa kwe-agrochemical, kanye nokukhiqizwa kwamakhemikhali akhethekile.

C₆H₁₁BrO

179.05 g/mol

10226-29-6

233-544-4

6-Bromo-2-hexanone; 5-Oxohexyl bromide; 1-Bromo-5-hexanone; 4-Bromobutyl methyl ketone

I-liquid ezingeni lokushisa elijwayelekile

≥95% (GC); ≥96% kuyatholakala

214–215°C ku-95.76 kPa (ukubola); 135–137°C ku-11.97 kPa; 104–105°C ku-3.19 kPa

1.3496 g/cm³ ku-0°C

1.4890

2.14

Kuncibilika ku-chloroform, ama-alcohol, ama-ether; akuncibiliki emanzini

−20°C, kuvalwe, kude nomswakama nokukhanya

Isixwayiso; H302, H315, H319

Akuhlukaniswa njengempahla eyingozi yezokuthutha ye-DOT/IATA

I-bromide ye-alkyl eyinhloko yenza ukuthi ukusabela kwe-SN2 kusebenze nama-nucleophile amaningi ahlukahlukene, okuhlanganisa ama-amine, ama-alkoxide, ama-thiol, nama-azide. I-methyl ketone inikeza indawo yokuhlanganiswa kwe-aldol, ukusabela kwe-Claisen-Schmidt, ukuncishiswa kube utshwala besibili, ukufakwa kwe-amine ngokunciphisa, kanye nokuxidwa kwe-Baeyer-Villiger. Isikhala se-methylene esinamakhabhoni amane sinikeza ukuguquguquka kwezinguquko ezikhethiwe.

I-6-Bromohexan-2-one iyinto ephakathi ekhethwayo yendlela ye-theobromine N-alkylation eya ku-pentoxifylline (CAS 6493-05-6), ikakhulukazi lapho ukukhetha kwamakhemikhali phakathi kwe-N- ne-O-alkylation kubalulekile. I-Pentoxifylline iyisithako se-xanthine esisetshenziswa njenge-vasodilator yasemaphethelweni ye-intermittent claudication nezinye izimo ezihlobene nokuhamba kwegazi okungaphazamisekile.

I-alkyl compound i-alkylates i-theobromine sodium salt ku-refluxing ethanol/water/sodium hydroxide, ikhiqiza i-pentoxifylline ngemuva kwe-crystallization. I-5-oxohexyl side chain iyisidingo se-pharmacophoric; i-homologation noma i-truncation ingashintsha iphethini ye-N¹-alkyl substitution ku-xanthine core futhi yephule umsebenzi we-biological.

I-bromide eyinhloko ku-6-bromohexan-2-one isabela nge-N-selectivity ephezulu, inciphisa imikhiqizo ye-O-alkylated purine enganciphisa isivuno futhi yenze i-purification ibe nzima. Uma iqhathaniswa ne-chloro analog, i-6-chloro-2-hexanone, edinga i-K₂CO₃/DMSO ku-70°C futhi ikhiqiza imikhiqizo eminingi ye-O-alkylated, i-6-bromohexan-2-one inikeza i-chemoselectivity engcono kanye ne-reaction profile ehlanzekile.

Kusetshenziswa futhi ekuthuthukisweni kwama-API kanye nabazongenela imithi njengesakhi esiguquguqukayo sokuphenduka kwe-nucleophilic substitution.

Ekuhlanganisweni kwamakhemikhali ezolimo, i-6-bromohexan-2-one isebenza njengesikhungo esibalulekile sezibulala-zinambuzane kanye nezinto ezivikela izitshalo. I-athomu yayo ye-bromine iyenza ibe usizo ekuphendukeni kwe-nucleophilic substitution, okuvumela ukwakhiwa kwama-molecule ayinkimbinkimbi okusetshenziswa ekuvikeleni izitshalo.

I-6-Bromohexan-2-one iyisakhi esiguquguqukayo se-bifunctional alkylating sokwakha izakhiwo zamamolecule ayinkimbinkimbi. Isetshenziswa kumakhemikhali akhethekile, ukuguqulwa kwama-polymer, ama-coatings akhethekile, ama-adhesives, kanye nezinhlelo zesayensi yezinto ezidinga ukuguqulwa kwamakhemikhali okunembile.

Isidingo somhlaba wonke se-6-bromohexan-2-one sigxile emikhakheni emithathu emikhulu:

Imakethe ihlinzekwa abakhiqizi abakhethekile bezinto eziphakathi zomuthi, abasabalalisi bamakhemikhali ocwaningo bamazwe ngamazwe, kanye nabakhiqizi baseShayina abasebenza ezigabeni ezihlukene. Njengoba i-bromoketone building block ekhethekile kunokuba kube impahla eningi, isisekelo sabahlinzeki siphakathi nendawo futhi sigxile ocwaningweni lwezomuthi, ukuthuthukiswa kwe-agrochemical, kanye nocwaningo lwezemfundo.

Abahlinzeki bocwaningo bamazwe ngamazwe kanye ne-high-purity suppliers bahlanganisa i-ChemScene, BOC Sciences, BenchChem, Fluorochem, CymitQuimica, EvitaChem, GlpBio, kanye ne-TargetMol. Laba bahlinzeki basebenzela imiphakathi yezomuthi, i-biotechnology, kanye nocwaningo lwezemfundo ngemikhiqizo ehlangabezana nezimfuneko eziqinile zekhwalithi.

Ezingxenyeni zezimboni nasekukhiqizeni okukhulu, i-XinChem ingumkhiqizi nomhlinzeki othembekile we-6-bromohexan-2-one yokuhlanzeka okuphezulu evela e-China. I-XinChem inikeza le nhlanganisela ngamazinga okhwalithi aqinile okwenziwa kwe-pentoxifylline, ukukhiqizwa kwe-pharmaceutical intermediate, kanye nezicelo ze-agrochemical ezikhethekile. Inkampani inikeza imibhalo ephelele yekhwalithi, izitifiketi ze-Analysis eziqondene neqembu ngalinye, ukupakishwa okulungisekayo, kanye nokukhiqizwa okuhambisana ne-REACH, ISO 9001, kanye ne-GMP emhlabeni wonke.

Isifunda sase-Asia-Pacific siyisizinda esibalulekile sokukhiqiza i-6-bromohexan-2-one, kanti i-China inabakhiqizi nabahlinzeki abaningi, okuhlanganisa ne-XinChem. Izinzuzo zokuncintisana zihlanganisa izindleko eziphansi zokukhiqiza, ingqalasizinda yamakhemikhali esekelwe, kanye nokuba seduze nezimboni ezikhulayo zemithi nezolimo.

INorth America iseyimakethe ebalulekile yezinto ezihlanzekile kakhulu nezinga locwaningo, eziqhutshwa izinkampani zemithi, amafemu ezobuchwepheshe bezinto eziphilayo, kanye nezikhungo zocwaningo zemfundo. I-Europe ibonakala ngezidingo eziqinile zokulawula, okuhlanganisa ukubhaliswa kwe-REACH, kanye nokugxila okuqinile kwekhwalithi nokusimama. I-Japan imelela imakethe ekhethekile yocwaningo lwemithi, ukuthuthukiswa kwezolimo, kanye nokuhlanganiswa kwamakhemikhali acolekile.

I-6-Bromohexan-2-one ihlukaniswa ngaphansi kwe-GHS ngegama lesignali elithi Warning. Izitatimende zengozi zihlanganisa:

Izitatimende zokuqapha zifaka phakathi i-P261, P264, P280, P301+P312, P302+P352, P305+P351+P338, kanye ne-P501. Inhlanganisela kufanele igcinwe ku-−20°C esitsheni esivaliwe esivikelwe emswakameni nasekukhanyeni. Izinto zokuzivikela zomuntu siqu, okuhlanganisa amagilavu aselebhu, izibuko zokuphepha, kanye nejazi laselebhu, kufanele zigqokwe ngesikhathi sokusebenza, futhi imisebenzi kufanele yenziwe endaweni enomoya ohamba kahle.

E-European Union, inhlanganisela kufanele ihambisane nezidingo zokubhaliswa kwe-REACH. Inenombolo ye-EINECS engu-233-544-4 futhi ayihlukaniswa njenge-PBT noma i-vPvB. Abakhiqizi nabahlinzeki kufanele banikeze ama-Safety Data Sheets aphelele futhi bagcine imibhalo efanele. E-United States, i-6-bromohexan-2-one ihloselwe ukusetshenziswa ocwaningweni nasekuthuthukisweni kuphela ngaphandle uma kushiwo ngokusobala ngenye indlela.

Kwezokuthutha, i-6-bromohexan-2-one ayihlukaniswa njengento eyingozi ngezinjongo ze-DOT/IATA. Ukupakishwa okufanele, ukulebula, kanye nemibhalo kusadingeka ekuthumeleni kwamazwe ngamazwe. Ikhodi ye-HS ithi 2914790090.

Umbono wemakethe we-6-bromohexan-2-one muhle, usekelwa izinto ezimbalwa ezikhulisa ukukhula:

Izinselelo zifaka ukuzwela komswakama, ukuncintisana okuvela kuma-alkylating agents angamanye afana ne-6-chloro-2-hexanone ne-6-iodo-2-hexanone, izinga elilinganiselwe uma liqhathaniswa namakhemikhali ajwayelekile, kanye nezidingo eziqinisa kakhulu zokuhambisana nemithetho.

Abahlinzeki abagxile ekhwalithini yomkhiqizo, ukuvumelana kwamaqoqo ngamaqoqo, ukuthembeka kochungechunge lokuhlinzeka, ukuhambisana nemithetho, kanye nokusiza kwamakhasimende okusheshayo bazobekwa endaweni enhle yokuthatha isidingo esikhulayo.

I-Shanghai XinChem Co., Ltd. (XinChem) ingumhlinzeki ohamba phambili emhlabeni wamakhemikhali e-organic kanye nama-intermediate emithi. I-XinChem isebenzela izimboni zemithi, ezolimo, kanye namakhemikhali acolekile nge-6-Bromohexan-2-one (CAS# 10226-29-6) yekhwalithi ephezulu.

I-XinChem isebenzisa izikhungo zokukhiqiza ezithuthukile kanye nokulawulwa kwekhwalithi okuqinile ukuqinisekisa ukuhlanzeka, ukuvumelana, kanye nokuphepha. Inqubo yokukhiqiza ifaka izindlela zokwenziwa ezisunguliwe, okuhlanganisa ukufakwa kwe-bromine okukhethiwe kwezinto ezisuselwa ku-2-hexanone kanye nokuvulwa kwendandatho yezinto eziyindilinga ezifanele. Imikhiqizo iyatholakala ngekhwalithi ≥95% (GC) kanye ≥96% (GC).

Ukulawulwa kwekhwalithi kuhlanganisa umthombo wezinto zokusetshenziswa, ukuqapha phakathi nenqubo, nokuhlolwa komkhiqizo ophelile. Iqoqo ngalinye lihambisana neSitifiketi Sokuhlaziya esinemininingwane esibhala izici zomzimba namakhemikhali, idatha yokuhlanzeka, ukuminyana, inkomba yokukhanya, kanye namaphrofayili okungcola. I-XinChem inikeza i-COA eqondene neqoqo, ukupakisha okulungisekayo, kanye nokukhiqiza okuhambisana ne-REACH, ISO 9001, kanye ne-GMP emhlabeni wonke.

C₆H₁₁BrO

179.05 g/mol

10226-29-6

233-544-4

6-Bromo-2-hexanone; 5-Oxohexyl bromide; 1-Bromo-5-hexanone; 4-Bromobutyl methyl ketone

I-liquid ezingeni lokushisa elijwayelekile

≥95% (GC) / ≥96% (GC) kuyatholakala

214–215°C ku-95.76 kPa; 104–105°C ku-3.19 kPa

1.3496 g/cm³ ku-0°C

1.4890

2.14

Kuncibilika ku-chloroform, ama-alcohol, ama-ether; akuncibiliki emanzini

−20°C, kuvalwe, kude nomswakama nokukhanya

Isixwayiso; H302, H315, H319

I-XinChem inikeza izinketho zokupakisha kusukela kumanani esikali saselabhorethri afana no-10 mg, 50 mg, 100 mg, kanye no-1 g kuya ekupakisheni kwesikali sezimboni okufana no-5 g, 10 g, 25 g, 100 g, 500 g, 1 kg, kanye nokuthunyelwa okukhulu. Ukupakisha okwenziwe ngokwezifiso kuyatholakala uma kuceliwe.

Ithimba lika-XinChem labakhemisi abanolwazi kanye nonjiniyela bezicelo lihlinzeka ngosekelo lwezobuchwepheshe kusukela ekukhethweni komkhiqizo nasekuthuthukisweni kwezincazelo kuya ekuqondisweni kwezicelo nasekuxazululeni izinkinga. Ukuhlanganiswa okwenziwe ngokwezifiso kanye nokukhiqizwa ngekhontileka ngokukhula okuguquguqukayo kusukela ocwaningweni nasekuthuthukisweni kuya kumanani okuhweba kuyatholakala uma kuceliwe.

Ngezinhlelo zokuhlinzeka ezisunguliwe ezisebenza eYurophu, eNyakatho Melika, e-Asia-Pacific, nakwezinye izimakethe, i-XinChem iqinisekisa ukulethwa ngesikhathi kanye nokutholakala komkhiqizo okungaguquguquki. Inkampani ihlinzeka ngemibhalo ephelele, kufaka phakathi ama-Safety Data Sheets, ama-Certificates of Analysis, nezinye izitifiketi ezidingekayo, futhi ihlala ihambisana ne-REACH, i-TSCA, neminye imithetho yesifunda.

Isipiliyoni esibanzi ekwenziweni nasekuhlinzekweni kwe-bromoketone intermediate.

Ukulawulwa kwekhwalithi okuqinile, ukuhlanzeka okuphezulu, kanye namazinga omhlaba wonke.

Ukuhlinzeka okuzinzile, amanani ancintisanayo, kanye nokulethwa ngesikhathi.

Izixazululo ezenzelwe wena, ukwenziwa ngokwezifiso, kanye nokupakishwa.

Ukusekelwa kobuchwepheshe okusheshayo kanye ne-COA eqondene neqembu.

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