Isingeniso 1′-hydroxyestragole (CAS#51410-44-7)

Izici Zamakhemikhali Nezomzimba
Ifomula yamangqamuzana: C ₁₀ H ₁₂ O ₂
Isisindo samangqamuzana: 164.20 g/mol
Ukubukeka: Uketshezi olungenawo umbala noma oluphuzi ngokukhanyayo oluguquguqukayo
Iphuzu lokubila: 277.2 ° C (760 mmHg)
Ukuminyana: 1.051 g/cm ³ (20 ° C)
Iphuzu lokukhanya: 119.6 ° C
Ingcindezi yomhwamuko: 0.0022 mmHg (25 ° C)
LogP: Cishe 1.723 (i-lipophilic elinganiselayo, ingena kalula kuma-biofilm)
Izici zesakhiwo: Izinto ezisuselwa ku-Phenylpropanoid, eziqukethe imethoxy kanye namaketanga aseceleni e-allyl alcohol, ziyimethaboliti e-hydroxylated ye-estragole.
Ubuthi Nezingozi Zempilo
Umdlavuza:
1 '- Hydroxyartemisinin iyimetabolite eyinhloko ebangela umdlavuza wesibindi ye-artemisinin, ebangela ukwakheka kwe-DNA adducts yamaseli esibindi ezilwaneni, ephakeme kakhulu kune-parent compound.
I-International Agency for Research on Cancer (IARC) ayikakahlukanisi ngokwahlukile, kodwa i-European Food Safety Authority (EFSA) iyivimbile njengesengezo sokudla ngenxa yobuthi bayo bemfuzo.
Ukuguquka:
Ukuphuka kwama-chromosome kungabangelwa kumaseli e-HepG2-CYP1A2, okubonisa umkhawulo wokwakheka kwe-DNA adduct kanye nobuthi obuncike kumthamo.
Indlela yobuthi besibindi:
Ngemva kwe-catalytic hydroxylation eyenziwa yi-CYP1A2, i-SULT1A1 iqhubeka nokufakwa i-sulfate ukuze ikhiqize ama-intermediates asebenzayo kakhulu e-electrophilic abopha ngokuqinile kuma-DNA bases (njenge-guanine), okuholela ekuguqulweni kofuzo nokulimala kwamaseli esibindi.
Ubuthi obukhulu:
Ukuhlukaniswa kwe-GHS: GHS07 (ingozi yezempilo), GHS08 (ukudala umdlavuza)
Incazelo yengozi: H317 (ingase ibangele ukungezwani nesikhumba), H351 (kusolakala ukuthi iyingozi yomdlavuza), H341 (kusolakala ukuthi yenza umonakalo ezakhiweni zofuzo), H302 (iyingozi uma igwinywa).