Izici Zamakhemikhali:
Ifomula yamangqamuzana C8H9NO2
Isisindo seMolar 151.16
Ubukhulu 1.168±0.06 g/cm3(Kuqagelwe)
Iphuzu Lokuncibilika 201°C (dec.)(lit.)
Iphuzu lokubila 173-174 °C (Ingcindezi: 14 Torr)
Iphoyinti lokushisa elisheshayo 161.9°C
Ingcindezi yomhwamuko 2.59E-05mmHg ku-25°C
I-4-Aminophenylacetic acid (4-APA) iyi-intermediate yemithi esebenza ngezindlela eziningi enezinhlelo zokusebenza ezihlanganisa izindawo eziningi zokwelapha:
| Umkhakha Wokusetshenziswa | Izinsetshenziswa Eziyinhloko |
|---|---|
| Ama-β-Lactam Antibiotics | Isandulela esibalulekile ekwakhiweni kwe-ampicillin, cephalexin, cefradine, namanye ama-antibiotic e-β-lactam. Isakhiwo se-4-APA sisebenza njenge-side chain kuma-derivatives e-semisynthetic penicillin ne-cephalosporin. |
| Imithi ye-CNS | Isetshenziswa ekwenziweni kwama-API okwelapha ukucindezeleka, isifo sokuwa, kanye nezifo ezingapheliyo zobuhlungu. |
| Imithi Yezinhlungu Nezokulwa Nokuvuvukala | Isebenza njenge-intermediate ebalulekile ekwenziweni kwe-acetaminophen (paracetamol) ne-atenolol. |
| Ukuhlanganiswa Kwama-Peptide | Isebenza njenge-intermediate eguquguqukayo ekuhlanganiseni ama-peptide kanye nokuthuthukiswa kwezidakamizwa ze-peptidomimetic. Isakhiwo se-amino-carboxylate sivumela ukwakheka kwesibopho se-amide ukuze kwandiswe uchungechunge lwe-peptide. |
| Ama-Kinase Inhibitors Aqondisiwe | Isetshenziswa njenge-intermediate ekwenziweni kwama-peptidomimetics kanye nama-kinase inhibitors aqondiwe ezinhlelweni ze-oncology. |
| Izifundo Zokuvinjwa kwe-PepT1 | Isebenza njengesivimbeli esincintisanayo esingahambi esithwala ama-peptide e-epithelial i-PepT1, esetshenziswa ocwaningweni lokuthutha ama-peptide. |
| Amakhemikhali Ezolimo | Isetshenziswa ekwakhiweni kwezibulala-zinambuzane eziningi kanye nezixube zokubulala ukhula. |
| Imboni Yodayi Nezingulube | Isetshenziswa njenge-intermediate ekwakhiweni kodayi be-azo kanye nezimibala ezikhethekile. |
Amakhono Okuthuthukisa Ngokwezifiso:
- ✅ Ukwenziwa ngokwezifiso kwezinto ezisuselwa ku-4-APA (ama-ester, ama-amide, ama-salts)
- ✅ Ukulungiselelwa komzila wokukhiqiza okukhulu okungabizi kakhulu
- ✅ Ukwakhiwa kwezinto ezingcolile kanye nezindinganiso zokubhekisela
- ✅ Ukuthuthukiswa kwenqubo kusuka kugramu kuya esikalini samathani
- ✅ Ukuhlanganiswa kwama-peptide kanye ne-conjugation chemistry
| Ipharamitha | Ukucaciswa |
|---|---|
| Igama Lomkhiqizo | 4-Aminophenylacetic acid (p-Aminophenylacetic acid; 4-APA) |
| Inombolo ye-CAS | 1197-55-3 |
| Ifomula ye-Molecular | C₈H₉NO₂ |
| Isisindo Samangqamuzana | 151.16–151.17 g/mol |
| Igama le-IUPAC | 2-(4-Aminophenyl)acetic acid |
| Ukubukeka | I-powder ye-crystalline engenambala kuya kokuphuzi okukhanyayo |
| Ukuhlanzeka (Izinga Lemithi) | ≥99.0% (HPLC) |
| Ukuhlanzeka (Izinga Locwaningo) | ≥98.0% (HPLC) |
| Iphuzu lokuncibilika | 199–201°C (iyahlakazeka) |
| Ukuncibilika | Incibilika kuma-alcohol nezixazululo ze-alkali; incibilika kancane emanzini ashisayo |
| Okuqukethwe Kwamanzi (KF) | ≤0.5% |
| Izincibilikisi Ezisele | Ihlangabezana nemihlahlandlela ye-ICH Q3C |
| Izinsimbi Ezisindayo | ≤10 ppm |
| Inombolo ye-EINECS | 214-828-7 |
| I-PubChem CID | 14533 |
| Ukhiye we-InChI | CSEWAUGPAQPMDC-UHFFFAOYSA-N |
| SMILES | NC1=CC=C(CC(O)=O)C=C1 |
| Ikhodi ye-HS (Ukuthunyelwa Kwangaphandle e-China) | 29224999 |
| Izimo Zokugcina | Gcina isitsha sivalwe ngokuqinile endaweni eyomile, enomoya omuhle. Vikela ekukhanyeni nasezintweni ezinamanzi. |
| Isikhathi sokusebenza | Izinyanga ezingama-24 ngaphansi kokugcinwa okunconywayo |
S22 - Ungaphefumuli uthuli.
S24/25 - Gwema ukuthintana nesikhumba namehlo.
Sethula i-4-Aminophenylacetic Acid, inhlanganisela yamakhemikhali esebenza ngezindlela eziningi enokusetshenziswa okubanzi ekwenziweni kwezinto eziphilayo kanye nemboni yemithi. Ivamise ukutholakala njengamakristalu amhlophe kuya kokuphuzi okwenza kube lula ukuyiphatha nokuyisebenzisa.
Isuselwa ekuhlanganisweni kwezinto ezimbili eziyisisekelo zamakhemikhali; i-aniline ne-glycolic acid, i-4-Aminophenylacetic Acid isetshenziswa kabanzi enqubweni yokukhiqiza ama-pharmaceutical intermediates ahlukahlukene kanye nama-API.
Ukusetshenziswa okuyinhloko kwe-4-Aminophenylacetic Acid kukusetshenziswa njengento eluhlaza ekwenziweni kwezinto eziphilayo zamakhemikhali. Iyisithako esibalulekile ekukhiqizweni kwama-intermediate afana ne-4-Aminobenzeneacetic Acid, ebalulekile ekukhiqizweni kwemithi, izingulube zokwenziwa, kanye namakhemikhali ezolimo
Embonini yezemithi, i-4-Aminophenylacetic Acid isetshenziswa kabanzi ekukhiqizeni ama-API. Idlala indima ebalulekile ekwakhiweni kwezidakamizwa ezisetshenziselwa ukwelapha izimo zempilo ezahlukahlukene ezifana nokudangala, isifo sokuwa, kanye nezinhlungu ezingapheli. Le nhlanganisela iyisithako esiyinhloko ezidakamizweni ezifana ne-Gabapentin ne-Pregabalin, zombili ezisetshenziselwa ukwelapha isifo sokuwa. Le Acid futhi iyisithako esibalulekile ekukhiqizeni i-Diclofenac, isidakamizwa esinamandla esingeyona i-steroidal anti-inflammatory esisetshenziselwa ukudambisa izinhlungu.
Ukubaluleka kwe-4-Aminophenylacetic Acid akunakweqiwa phakathi enqubweni yokukhiqiza ama-intermediates nama-API asetshenziswa embonini yezemithi. Izici zayo eziyingqayizivele njengento eluhlaza ziyenza ibe yingxenye ebalulekile ekukhiqizeni imithi ehlukahlukene esetshenziswa izigidi zabantu emhlabeni wonke.
Uma kuziwa ekukhiqizeni, i-4-Aminophenylacetic Acid iyadingeka kakhulu ngenxa yokuzinza kwayo kwamakhemikhali, izinga lokusabela elisheshayo, ukuhlanzeka okuphezulu, kanye nokuqukethwe okuncane kwezinto ezingcolile. Lezi zici ziyenza isebenze kahle kakhulu enqubweni yokukhiqiza edinga ikhwalithi engaguquki futhi ethembekile.
Sengiphetha, i-4-Aminophenylacetic Acid iyinhlanganisela ebaluleke kakhulu esetshenziswa kabanzi ekuhlanganiseni izinto eziphilayo kanye nemboni yemithi. Iyisithako esibalulekile sokukhiqiza izinto eziphakathi kanye nama-API asetshenziswa ekukhiqizeni imithi ehlukahlukene. Ngezakhiwo zayo eziyingqayizivele kanye namazinga okuhlanzeka aphezulu, i-4-Aminophenylacetic Acid iyisithako esibalulekile ekukhiqizeni imithi ebalulekile esetshenziselwa ukwelapha izimo zempilo ezahlukahlukene. Ngempela, iyinhlanganisela eguquguqukayo enohlu olubanzi lwezinhlelo zokusebenza, futhi ukubaluleka kwayo enqubweni yokukhiqiza akunakweqiwa.
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