Isingeniso I-Carbamic acid, [(1S)-2-oxo-1-(phenylmethyl)-3-butenyl]-, 1,1-dimethylethyl ester (9CI)(CAS#137278-22-9)

Izici ezibonakalayo nokubukeka
Isimo: Uketshezi olungenambala kuya kokuphuzi okukhanyayo
Ukuncibilika: iyancibilika kuzincibilikisi ezejwayelekile zomzimba ezifana ne-dichloromethane, i-ethyl acetate, ne-ether, iyancibilika kancane emanzini
Ukuzinza: Izwa umswakama kanye ne-alkali eqinile, amaqembu e-Boc angavulwa ngaphansi kwezimo ze-acidic, futhi kudingeka agcinwe endaweni eyomile, enomoya we-inert
Iphuzu lokubila/iphuzu lokuncibilika: Iphuzu lokubila >200 ° C
Qaphela: Njengoba le nhlanganisela iyisihlanganisi esisebenza kakhulu, abahlinzeki bezentengiselwano ngokuvamile bayinikeza ngesimo somthamo ukuze bagweme ukugcinwa isikhathi eside kwemikhiqizo emsulwa.
Izinsizakusebenza eziyinhloko nezindawo zokusetshenziswa
Ukusetshenziswa okuyinhloko: Iyunithi yokwakha i-chiral ekuhlanganiseni imishanguzo
Izimo zokusetshenziswa ezijwayelekile:
Njenge-Boc evikelwe i-allyl carbamate, isetshenziselwa ukwakha i-peptide noma i-non peptide drug scaffolds equkethe izinto ezisuselwa ku-phenylalanine
Ibamba iqhaza ekuhlanganiseni i-nucleophilic kanye nasekuhlelweni kabusha kwama-cyclization ukwakha izinhlanganisela ze-nitrogen-containing heterocyclic (njenge-pyrrolidine ne-pyridine derivatives)
Njengesihlanganisi esibalulekile endleleni yokuhlanganisa imishanguzo elwa namagciwane kanye ne-anti-tumor