The Dr.Oligo 48 synthesizer is a medium-throughput DNA/RNA primer synthesis device, featuring 42 reagent bottle positions (including 32 special monomers) and capable of synthesizing longer, more complex sequences. Its features include an independent waste suction system, an automated pneumatic system, a new operating system based on Win10, and more, supporting the synthesis of various primers such as DNA, RNA, and LNA. The instrument is designed with a fully enclosed synthesis chamber and offers multiple configuration options to meet different experimental needs of users.